Using Brain Imaging to Distinguish Amongst Subtypes of Schizophrenia: An Investigation of Brain Muscarinic Receptors.

Genetic variation in glutamatergic genes moderates the effects of childhood adversity on brain volume and IQ in treatment-resistant schizophrenia

Suriati Mohamed Saini, Chad A Bousman, Serafino G Mancuso, Vanessa Cropley, Tamsyn E Van Rheenen, Rhoshel K Lenroot, Jason Bruggemann, Cynthia S Weickert, Thomas W Weickert, Suresh Sundram, Ian P Everall, Christos Pantelis

2023-09-14

Predicting individual improvement in schizophrenia symptom severity at 1-year follow-up: Comparison of connectomic, structural, and clinical predictors

Akhil Kottaram, Leigh A Johnston, Ye Tian, Eleni P Ganella, Liliana Laskaris, Luca Cocchi, Patrick McGorry, Christos Pantelis, Ramamohanarao Kotagiri, Vanessa Cropley, Andrew Zalesky

2020-08-15

In a machine learning setting, this study aims to compare the prognostic utility of connectomic, brain structural, and clinical/de..

Linking cortical and connectional pathology in schizophrenia

MA Di Biase, VL Cropley, L Cocchi, A Fornito, F Calamante, EP Ganella, C Pantelis, A Zalesky

2019-06-18

Schizophrenia is associated with cortical thickness (CT) deficits and breakdown in white matter microstructure. Whether these path..

The effects of a muscarinic receptor 1 gene variant on executive and non-executive cognition in schizophrenia spectrum disorders

SP Carruthers, V Cropley, C Bousman, IP Everall, E Neill, C Pantelis, PJ Sumner, EJ Tan, K Bozaoglu, EHX Thomas, TE Van Rheenen, CT Gurvich, SL Rossell

2019-03-01

Individuals with schizophrenia who are homozygous at the c.267C > A (rs2067477) single nucleotide polymorphism within the muscarin..

An Interleukin-1 beta (IL1B) haplotype linked with psychosis transition is associated with IL1B gene expression and brain structure

MS Mostaid, S Dimitrakopoulos, C Wannan, V Cropley, CS Weickert, IP Everall, C Pantelis, CA Bousman

2019-02-01

We investigated IL1B genetic variation previously associated with risk for transition to psychosis for its association with gene e..

The effects of a muscarinic receptor 1 gene variant on cortical thickness and surface area in schizophrenia

SP Carruthers, CT Gurvich, VL Cropley, C Pantelis, C Bousman, RK Lenroot, JM Bruggemann, T Weickert, SL Rossell

2018-10-30

Individuals with schizophrenia who are homozygous at the c.267C>A single nucleotide polymorphism (rs2067477) within the cholinergi..

Widespread Volumetric Reductions in Schizophrenia and Schizoaffective Patients Displaying Compromised Cognitive Abilities

TE Van Rheenen, V Cropley, A Zalesky, C Bousman, R Wells, J Bruggemann, S Sundram, D Weinberg, RK Lenroot, A Pereira, C Shannon Weickert, TW Weickert, C Pantelis

2018-04-06

Objective: Progress toward understanding brain mechanisms in psychosis is hampered by failures to account for within-group heterog..

Neuregulin-1 (NRG1) polymorphisms linked with psychosis transition are associated with enlarged lateral ventricles and white matter disruption in schizophrenia

CA Bousman, V Cropley, P Klauser, JL Hess, A Pereira, R Idrizi, J Bruggemann, MS Mostaid, R Lenroot, TW Weickert, SJ Glatt, IP Everall, S Sundram, A Zalesky, CS Weickert, C Pantelis

2018-04-01

Background Two single-nucleotide polymorphisms (SNPs) (rs4281084 and rs12155594) within the neuregulin-1 (NRG1) gene have been ass..

White matter connectivity disruptions in early and chronic schizophrenia

MA Di Biase, VL Cropley, BT Baune, J Olver, GP Amminger, C Phassouliotis, C Bousman, PD McGorry, I Everall, C Pantelis, A Zalesky

2017-12-01

Background White matter disruptions in schizophrenia have been widely reported, but it remains unclear whether these abnormalities..

Structural neuroimaging across early-stage psychosis: Aberrations in neurobiological trajectories and implications for the staging model

CF Bartholomeusz, VL Cropley, C Wannan, M Di Biase, PD McGorry, C Pantelis

2017-05-01

Objective: This review critically examines the structural neuroimaging evidence in psychotic illness, with a focus on longitudinal..

Accelerated gray and white matter deterioration with age in schizophrenia

VL Cropley, P Klauser, RK Lenroot, J Bruggemann, S Sundram, C Bousman, A Pereira, MA Di Biase, TW Weickert, CS Weickert, C Pantelis, A Zalesky

2017-03-01

Objective: Although brain changes in schizophrenia have been proposed to mirror those found with advancing age, the trajectory of ..

Neuroanatomical Predictors of Functional Outcome in Individuals at Ultra-High Risk for Psychosis

RLEP Reniers, A Lin, AR Yung, N Koutsouleris, B Nelson, VL Cropley, D Velakoulis, PD McGorry, C Pantelis, SJ Wood

2017-03-01

Most individuals at ultra-high risk (UHR) for psychosis do not transition to frank illness. Nevertheless, many have poor clinical ..

White Matter Disruptions in Schizophrenia Are Spatially Widespread and Topologically Converge on Brain Network Hubs

P Klauser, ST Baker, VL Cropley, C Bousman, A Fornito, L Cocchi, JM Fullerton, P Rasser, U Schall, F Henskens, PT Michie, C Loughland, SV Catts, B Mowry, TW Weickert, C Shannon Weickert, V Carr, R Lenroot, C Pantelis, A Zalesky

2017-03-01

White matter abnormalities associated with schizophrenia have been widely reported, although the consistency of findings across st..

Effects of cigarette smoking on cortical thickness in major depressive disorder

N Zorlu, VL Cropley, PK Zorlu, DH Delibas, ZH Adibelli, EP Baskin, ÖS Esen, E Bora, C Pantelis

2017-01-01

Findings of surface-based morphometry studies in major depressive disorder (MDD) are still inconsistent. Given that cigarette smok..

PET imaging of putative microglial activation in individuals at ultra-high risk for psychosis, recently diagnosed and chronically ill with schizophrenia

MA Di Biase, A Zalesky, G O'keefe, L Laskaris, BT Baune, CS Weickert, J Olver, PD McGorry, GP Amminger, B Nelson, AM Scott, I Hickie, R Banati, F Turkheimer, M Yaqub, IP Everall, C Pantelis, V Cropley

2017-01-01

We examined putative microglial activation as a function of illness course in schizophrenia. Microglial activity was quantified us..

Baseline grey matter volume of non-transitioned "ultra high risk" for psychosis individuals with and without attenuated psychotic symptoms at long-term follow-up

VL Cropley, A Lin, B Nelson, RLEP Reniers, AR Yung, CF Bartholomeusz, P Klauser, D Velakoulis, P McGorry, SJ Wood, C Pantelis

2016-06-01

Introduction: Two thirds of individuals identified as ultra-high risk (UHR) for psychosis do not transition to psychosis over the ..

Baseline grey matter volume of non-transitioned "ultra high risk" for psychosis individuals with and without attenuated psychotic symptoms at long-term follow-up

Vanessa L Cropley, Ashleigh Lin, Barnaby Nelson, Renate LEP Reniers, Alison R Yung, Cali F Bartholomeusz, Paul Klauser, Dennis Velakoulis, Patrick McGorry, Stephen J Wood, Christos Pantelis

2016-06-01

Microglial activation and progressive brain changes in schizophrenia

LE Laskaris, MA Di Biase, I Everall, G Chana, A Christopoulos, E Skafidas, VL Cropley, C Pantelis

2016-02-01

Schizophrenia is a debilitating disorder that typically begins in adolescence and is characterized by perceptual abnormalities, de..

Investigation of orbitofrontal sulcogyral pattern in chronic schizophrenia

VL Cropley, CF Bartholomeusz, P Wu, SJ Wood, T Proffitt, WJ Brewer, PM Desmond, D Velakoulis, C Pantelis

2015-11-30

Abnormalities of orbitofrontal cortex (OFC) pattern type distribution have been associated with schizophrenia-spectrum disorders. ..

The effect of a muscarinic receptor 1 gene variant on grey matter volume in schizophrenia

VL Cropley, E Scarr, A Fornito, P Klauser, CA Bousman, R Scott, MJ Cairns, PA Tooney, C Pantelis, B Dean

2015-11-30

Previous research has demonstrated that individuals with schizophrenia who are homozygous at the c.267C>A single nucleotide polymo..